A maple syrup extract alters lipid metabolism in obese type 2 diabetic model mice.

ABSTRACT:

Background

Some polyphenols are known to improve the symptoms of diabetes. In the present study, we investigated the effects of a polyphenol-rich extract of maple syrup (MSx) on a diabetic mouse model.

Methods

KK-A ^y mice were fed a normal or 0.05% MSx-supplemented diet for 42 days. Body weight, food intake, serum biochemical parameters, and fecal total bile acid were measured. Gene expression of liver and epididymal white adipose tissue (WAT) and cecal microbiota were analyzed. Data were analyzed with an unpaired two-tailed Student's t test or Welch's t test according to the results of the F test.

Results

Serum low-density lipoprotein cholesterol levels were significantly reduced in mice that consumed MSx. Hepatic genes r

SUBMITTER: Toyoda T 

PROVIDER: S-EPMC6894227 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature