The distributions of protein coding genes within chromatin domains in relation to human disease.

ABSTRACT:

Background

Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C. The unprecedented resolution of genome-wide interaction maps shows functional consequences that extend the initial thought of an efficient DNA packaging mechanism: gene regulation, DNA repair, chromosomal translocations and evolutionary rearrangements seem to be only the peak of the iceberg. One key concept emerging from this research is the topologically associating domains (TADs) whose functional role in gene regulation and their association with disease is not fully untangled.

Results

We report that the lower the number of protein coding genes inside TADs, the higher the tend

SUBMITTER: Muro EM 

PROVIDER: S-EPMC6894242 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature