Inhaled corticosteroids and FEV₁ decline in chronic obstructive pulmonary disease: a systematic review.

ABSTRACT: Rate of FEV₁ decline in COPD is heterogeneous and the extent to which inhaled corticosteroids (ICS) influence the rate of decline is unclear. The majority of previous reviews have investigated specific ICS and non-ICS inhalers and have consisted of randomised control trials (RCTs), which have specific inclusion and exclusion criteria and short follow up times. We aimed to investigate the association between change in FEV₁ and ICS-containing medications in COPD patients over longer follow up times.MEDLINE and EMBASE were searched and literature comparing change in FEV₁ in COPD patients taking ICS-containing medications with patients taking non-ICS-containing medications were identified. Titles, abstract, and full texts were screened and information extracted

SUBMITTER: Whittaker HR 

PROVIDER: S-EPMC6894275 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature