Immunomodulatory effects of interferon-γ on human fetal cardiac mesenchymal stromal cells.

ABSTRACT:

Background

Mesenchymal stromal cells (MSCs), due to their regenerative and immunomodulatory properties, are therapeutically used for diseases, including heart failure. As early gestational-phase embryonic tissues exhibit extraordinary regenerative potential, fetal MSCs exposed to inflammation offer a unique opportunity to evaluate molecular mechanisms underlying preferential healing, and investigate their inherent abilities to communicate with the immune system during development. The principal aim of this study was to evaluate the effects of interferon-γ (IFNγ) on the immunomodulatory effects of first-trimester human fetal cardiac (hfc)-MSCs.

Methods

hfcMSCs (gestational week 8) were exposed to IFNγ, with subsequent analysis of the whole transcriptome, based on RNA sequenci

SUBMITTER: Grinnemo KH 

PROVIDER: S-EPMC6894330 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature