Epigenetic therapy of novel tumour suppressor ZAR1 and its cancer biomarker function.

ABSTRACT:

Background

Cancer still is one of the leading causes of death and its death toll is predicted to rise further. We identified earlier the potential tumour suppressor zygote arrest 1 (ZAR1) to play a role in lung carcinogenesis through its epigenetic inactivation.

Results

We are the first to report that ZAR1 is epigenetically inactivated not only in lung cancer but also across cancer types, and ZAR1 methylation occurs across its complete CpG island. ZAR1 hypermethylation significantly correlates with its expression reduction in cancers. We are also the first to report that ZAR1 methylation and expression reduction are of clinical importance as a prognostic marker for lung cancer and kidney cancer. We further established that the carboxy (C)-terminally present zinc-finger of ZA

SUBMITTER: Deutschmeyer V 

PROVIDER: S-EPMC6894338 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature