A Prospective Observational Study to Evaluate the Effects of Long-Acting Somatostatin Analogs on ⁶⁸Ga-DOTATATE Uptake in Patients with Neuroendocrine Tumors.

ABSTRACT: Patients with neuroendocrine tumors (NETs) are often treated with somatostatin analogs (SSAs) for control of symptoms and tumor growth. Such therapy could theoretically lead to misinterpretation of somatostatin receptor imaging with ⁶⁸Ga-DOTATATE PET/CT by interfering with tracer-receptor binding. Guidelines recommend an interval of 3-4 wk between the last dose and imaging. The aim of this study was to evaluate if long-acting (LA) SSA treatment changes the uptake of ⁶⁸Ga-DOTATATE in patients with NETs. Methods: From 2013 to 2016, 296 patients with, or under evaluation for, NETs were included in this prospective observational study. The effect of LA SSA on tracer uptake was evaluated in 2 main patient populations: those undergoing ⁶⁸Ga-DOTATATE PET/CT

SUBMITTER: Galne A 

PROVIDER: S-EPMC6894372 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature