Biodistribution and Dosimetry of Intraventricularly Administered ¹²⁴I-Omburtamab in Patients with Metastatic Leptomeningeal Tumors.

ABSTRACT: Radiation dose estimations are key for optimizing therapies. We studied the role of ¹²⁴I-omburtamab (8H9) given intraventricularly in assessing the distribution and radiation doses before ¹³¹I-omburtamab therapy in patients with metastatic leptomeningeal disease and compared it with the estimates from cerebrospinal fluid (CSF) sampling. Methods: Patients with histologically proven malignancy and metastatic disease to the central nervous system or leptomeninges who met eligibility criteria for ¹³¹I-omburtamab therapy underwent immuno-PET imaging with ¹²⁴I-8H9 followed by ¹³¹I-8H9 antibody therapy. Patients were imaged with approximately 74 MBq of intraventricular ¹²⁴I-omburtamab via an Ommaya reservoir. Whole-body PET

SUBMITTER: Pandit-Taskar N 

PROVIDER: S-EPMC6894373 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature