Molecular Imaging of Fibroblast Activity After Myocardial Infarction Using a ⁶⁸Ga-Labeled Fibroblast Activation Protein Inhibitor, FAPI-04.

ABSTRACT: Heart failure remains a major source of late morbidity and mortality after myocardial infarction (MI). The temporospatial presence of activated fibroblasts in the injured myocardium predicts the quality of cardiac remodeling after MI. Therefore, monitoring of activated fibroblasts is of great interest for studying cardiac remodeling after MI. Fibroblast activation protein (FAP) expression is upregulated in activated fibroblasts. This study investigated the feasibility of imaging activated fibroblasts with a new ⁶⁸Ga-labeled FAP inhibitor (⁶⁸Ga-FAPI-04) for PET imaging of fibroblast activation in a preclinical model of MI. Methods: MI and sham-operated rats were scanned with ⁶⁸Ga-FAPI-04 PET/CT (1, 3, 6, 14, 23, and 30 d after MI) and with ¹⁸

SUBMITTER: Varasteh Z 

PROVIDER: S-EPMC6894377 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature