A Fully Automatic Technique for Precise Localization and Quantification of Amyloid-β PET Scans.

ABSTRACT: Spatial heterogeneity in the accumulation of amyloid-β plaques throughout the brain during asymptomatic as well as clinical stages of Alzheimer disease calls for precise localization and quantification of this protein using PET imaging. To address this need, we have developed and evaluated a technique that quantifies the extent of amyloid-β pathology on a millimeter-by-millimeter scale in the brain with unprecedented precision using data from PET scans. Methods: An intermodal and intrasubject registration with normalized mutual information as the cost function was used to transform all FreeSurfer neuroanatomic labels into PET image space, which were subsequently used to compute regional SUV ratio (SUVR). We have evaluated our technique using postmortem histopathologic staining data

SUBMITTER: Tahmi M 

PROVIDER: S-EPMC6894379 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature