Imaging of Chemotherapy-Induced Acute Cardiotoxicity with ¹⁸F-Labeled Lipophilic Cations.

ABSTRACT: Many chemotherapy agents are toxic to the heart, such that increasing numbers of cancer survivors are now living with the potentially lethal cardiovascular consequences of their treatment. Earlier and more sensitive detection of chemotherapy-induced cardiotoxicity may allow improved treatment strategies and increase long-term survival. Lipophilic cation PET tracers may be suitable for early detection of cardiotoxicity. This study aimed to evaluate an ¹⁸F-labeled lipophilic phosphonium cation, [1-(2-¹⁸F-fluoroethyl),1H[1,2,3]triazole-4-ethylene]triphenylphosphonium bromide (¹⁸F-MitoPhos), as a cardiac imaging agent, comparing it with leading PET and SPECT lipophilic cationic tracers before further assessing its potential for imaging cardiotoxicity in

SUBMITTER: McCluskey SP 

PROVIDER: S-EPMC6894381 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature