A systematic analysis highlights multiple long non-coding RNAs associated with cardiometabolic disorders.

ABSTRACT: Genome-wide association studies (GWAS) have identified many susceptibility loci for cardiometabolic disorders. Most of the associated variants reside in non-coding regions of the genome including long non-coding RNAs (lncRNAs), which are thought to play critical roles in diverse biological processes. Here, we leveraged data from the available GWAS meta-analyses on lipid and obesity-related traits, blood pressure, type 2 diabetes, and coronary artery disease and identified 179 associated single-nucleotide polymorphisms (SNPs) in 102 lncRNAs (p-value?

SUBMITTER: Ghanbari M 

PROVIDER: S-EPMC6894420 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature