Propofol inhibits stromatoxin-1-sensitive voltage-dependent K⁺ channels in pancreatic β-cells and enhances insulin secretion.

ABSTRACT:

Background

Proper glycemic control is an important goal of critical care medicine, including perioperative patient care that can influence patients' prognosis. Insulin secretion from pancreatic β-cells is generally assumed to play a critical role in glycemic control in response to an elevated blood glucose concentration. Many animal and human studies have demonstrated that perioperative drugs, including volatile anesthetics, have an impact on glucose-stimulated insulin secretion (GSIS). However, the effects of the intravenous anesthetic propofol on glucose metabolism and insulin sensitivity are largely unknown at present.

Methods

The effect of propofol on insulin secretion under low glucose or high glucose was examined in mouse MIN6 cells, rat INS-1 cells, and mouse pancreat

SUBMITTER: Kusunoki M 

PROVIDER: S-EPMC6894434 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature