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Circulating calprotectin (S100A8/A9) is higher in rheumatoid arthritis patients that relapse within 12?months of tapering anti-rheumatic drugs.

ABSTRACT: OBJECTIVE:To investigate whether calprotectin (S100A8/A9 or MRP8/14), an inflammatory complex released by monocytes, could indicate residual subclinical inflammation in rheumatoid arthritis (RA) patients who are in stable remission on disease-modifying anti-rheumatic drugs (DMARDs) and serve as a marker for disease flare after DMARD tapering. METHODS:We used data from two trials. Patients from the IMPROVED study had early (

SUBMITTER: de Moel EC 

PROVIDER: S-EPMC6894482 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Circulating calprotectin (S100A8/A9) is higher in rheumatoid arthritis patients that relapse within 12 months of tapering anti-rheumatic drugs.

de Moel Emma C EC   Rech Jürgen J   Mahler Michael M   Roth Johannes J   Vogl Thomas T   Schouffoer Anne A   Goekoop Robbert J RJ   Huizinga Tom W J TWJ   Allaart Cornelia F CF   Toes René E M REM   Schett Georg G   van der Woude Diane D  

Arthritis research & therapy 20191205 1

<h4>Objective</h4>To investigate whether calprotectin (S100A8/A9 or MRP8/14), an inflammatory complex released by monocytes, could indicate residual subclinical inflammation in rheumatoid arthritis (RA) patients who are in stable remission on disease-modifying anti-rheumatic drugs (DMARDs) and serve as a marker for disease flare after DMARD tapering.<h4>Methods</h4>We used data from two trials. Patients from the IMPROVED study had early (< 2 years) RA, and when they achieved disease activity sco  ...[more]

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