A wave of monocytes is recruited to replenish the long-term Langerhans cell network after immune injury.

ABSTRACT: A dense population of embryo-derived Langerhans cells (eLCs) is maintained within the sealed epidermis without contribution from circulating cells. When this network is perturbed by transient exposure to ultraviolet light, short-term LCs are temporarily reconstituted from an initial wave of monocytes but thought to be superseded by more permanent repopulation with undefined LC precursors. However, the extent to which this process is relevant to immunopathological processes that damage LC population integrity is not known. Using a model of allogeneic hematopoietic stem cell transplantation, where alloreactive T cells directly target eLCs, we have asked whether and how the original LC network is ultimately restored. We find that donor monocytes, but not dendritic cells, are the precursors of

SUBMITTER: Ferrer IR 

PROVIDER: S-EPMC6894529 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature