Ontology highlight
ABSTRACT:
SUBMITTER: Garriga E
PROVIDER: S-EPMC6894943 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Nature biotechnology 20191202 12
Multiple sequence alignments (MSAs) are used for structural<sup>1,2</sup> and evolutionary predictions<sup>1,2</sup>, but the complexity of aligning large datasets requires the use of approximate solutions<sup>3</sup>, including the progressive algorithm<sup>4</sup>. Progressive MSA methods start by aligning the most similar sequences and subsequently incorporate the remaining sequences, from leaf to root, based on a guide tree. Their accuracy declines substantially as the number of sequences is ...[more]