Molecular response of Deinococcus radiodurans to simulated microgravity explored by proteometabolomic approach.

ABSTRACT: Regarding future space exploration missions and long-term exposure experiments, a detailed investigation of all factors present in the outer space environment and their effects on organisms of all life kingdoms is advantageous. Influenced by the multiple factors of outer space, the extremophilic bacterium Deinococcus radiodurans has been long-termly exposed outside the International Space Station in frames of the Tanpopo orbital mission. The study presented here aims to elucidate molecular key components in D. radiodurans, which are responsible for recognition and adaptation to simulated microgravity. D. radiodurans cultures were grown for two days on plates in a fast-rotating 2-D clinostat to minimize sedimentation, thus simulating reduced gravity conditions. Subsequently, metabolites and

SUBMITTER: Ott E 

PROVIDER: S-EPMC6895123 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature