Comparative analysis of corrected tiger genome provides clues to its neuronal evolution.

ABSTRACT: The availability of completed and draft genome assemblies of tiger, leopard, and other felids provides an opportunity to gain comparative insights on their unique evolutionary adaptations. However, genome-wide comparative analyses are susceptible to errors in genome sequences and thus require accurate genome assemblies for reliable evolutionary insights. In this study, while analyzing the tiger genome, we found almost one million erroneous substitutions in the coding and non-coding region of the genome affecting 4,472 genes, hence, biasing the current understanding of tiger evolution. Moreover, these errors produced several misleading observations in previous studies. Thus, to gain insights into the tiger evolution, we corrected the erroneous bases in the genome assembly and gene set of ti

SUBMITTER: Mittal P 

PROVIDER: S-EPMC6895189 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature