Pten haploinsufficiency disrupts scaling across brain areas during development in mice.

ABSTRACT: Haploinsufficiency for PTEN is a cause of autism spectrum disorder and brain overgrowth; however, it is not known if PTEN mutations disrupt scaling across brain areas during development. To address this question, we used magnetic resonance imaging to analyze brains of male Pten haploinsufficient (Pten^+/-) mice and wild-type littermates during early postnatal development and adulthood. Adult Pten^+/- mice display a consistent pattern of abnormal scaling across brain areas, with white matter (WM) areas being particularly affected. This regional and WM enlargement recapitulates structural abnormalities found in individuals with PTEN haploinsufficiency and autism. Early postnatal Pten^+/- mice do not display the same pattern, instead exhibiting greater variabilit

SUBMITTER: Clipperton-Allen AE 

PROVIDER: S-EPMC6895202 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature