Postsynaptic Ca_V1.1-driven calcium signaling coordinates presynaptic differentiation at the developing neuromuscular junction.

ABSTRACT: Proper formation of neuromuscular synapses requires the reciprocal communication between motor neurons and muscle cells. Several anterograde and retrograde signals involved in neuromuscular junction formation are known. However the postsynaptic mechanisms regulating presynaptic differentiation are still incompletely understood. Here we report that the skeletal muscle calcium channel (Ca_V1.1) is required for motor nerve differentiation and that the mechanism by which Ca_V1.1 controls presynaptic differentiation utilizes activity-dependent calcium signaling in muscle. In mice lacking Ca_V1.1 or Ca_V1.1-driven calcium signaling motor nerves are ectopically located and aberrantly defasciculated. Axons fail to recognize their postsynaptic target structur

SUBMITTER: Kaplan MM 

PROVIDER: S-EPMC6895222 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature