Dietary yeast influences ethanol sedation in Drosophila via serotonergic neuron function.

ABSTRACT: Abuse of alcohol is a major clinical problem with far-reaching health consequences. Understanding the environmental and genetic factors that contribute to alcohol-related behaviors is a potential gateway for developing novel therapeutic approaches for patients that abuse the drug. To this end, we have used Drosophila melanogaster as a model to investigate the effect of diet, an environmental factor, on ethanol sedation. Providing flies with diets high in yeast, a routinely used component of fly media, increased their resistance to ethanol sedation. The yeast-induced resistance to ethanol sedation occurred in several different genetic backgrounds, was observed in males and females, was elicited by yeast from different sources, was readily reversible, and was associated with increased nutrie

SUBMITTER: Schmitt RE 

PROVIDER: S-EPMC6895393 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature