Diurnal Variation of Proton Density Fat Fraction in the Liver Using Quantitative Chemical Shift Encoded MRI.

ABSTRACT:

Background

Whole-organ, noninvasive techniques for the detection and quantification of nonalcoholic fatty liver disease features have clinical and research applications. However, the effect of time of day, hydration status, and meals are unknown factors with potential to impact bias, precision, reproducibility, and repeatability of chemical shift-encoded MRI (CSE-MRI) to quantify liver proton density fat fraction (PDFF).

Purpose

To assess the effect of diurnal variation on PDFF using CSE-MRI, including the effect of time of day, the effect of meals and hydration status, as well as the day to day variability.

Study type

Prospective.

Subjects

Eleven healthy subjects and nine patients with observed hepatic steatosis.

Field strength/sequences

A commercial qu

SUBMITTER: Colgan TJ 

PROVIDER: S-EPMC6895403 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature