Induction of NKG2D ligand expression on tumor cells by CD8⁺ T-cell engagement-mediated activation of nuclear factor-kappa B and p300/CBP-associated factor.

ABSTRACT: The ligands for the natural killer group 2 (NKG2D) protein render tumor cells susceptible to NKG2D-dependent immune cell attack. However, cancer cells escape from immune surveillance by downregulating NKG2D ligands. We previously discovered that engagement of activated CD8⁺ T cells and tumor cells induces NKG2D ligands on tumor cells, but the underlying mechanism remains to be defined. Both in vivo mouse tumor models and in vitro cell assays were performed to study the downstream signaling. Our results supported the notion that, upon engagement with the cognate receptors, CD137 ligand and CD40 initiates activation of nuclear factor-kappa B (NF-κB) signaling in tumor cells even in the absence of CD8⁺ T cells. Like tumor and CD8⁺ T cell contact-dependent NKG2

SUBMITTER: Hu J 

PROVIDER: S-EPMC6895417 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature