PGRMC2 is an intracellular haem chaperone critical for adipocyte function.

ABSTRACT: Haem is an essential prosthetic group of numerous proteins and a central signalling molecule in many physiologic processes^1,2. The chemical reactivity of haem means that a network of intracellular chaperone proteins is required to avert the cytotoxic effects of free haem, but the constituents of such trafficking pathways are unknown^3,4. Haem synthesis is completed in mitochondria, with ferrochelatase adding iron to protoporphyrin IX. How this vital but highly reactive metabolite is delivered from mitochondria to haemoproteins throughout the cell remains poorly defined^3,4. Here we show that progesterone receptor membrane component 2 (PGRMC2) is required for delivery of labile, or signalling haem, to the nucleus. Deletion of PGMRC2 in brown fat, which has a h

SUBMITTER: Galmozzi A 

PROVIDER: S-EPMC6895438 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature