Dietary riboflavin deficiency promotes N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in rats by inducing chronic inflammation.

ABSTRACT: Epidemiological studies in high-incidence areas of esophageal cancer in China suggest that environmental carcinogen N-nitrosomethylbenzylamine (NMBA) and riboflavin (RBF) deficiency may be the main risk factors for esophageal cancer. However, it is not clear that the combination induces cancer. Here, experiment (Exp) 1 evaluated the effects of NMBA and RBF deficiency individually or in combination on esophageal tumorigenesis. Male F344 rats were randomly assigned to 4 groups into a 2 (no NMBA vs. NMBA) × 2 (normal RBF vs. RBF-deficient) factorial design, including normal RBF (6 mg/kg, R₆), RBF-deficient (0 mg/kg, R₀), normal RBF combined with NMBA (R₆N), and RBF-deficient combined with NMBA (R₀N) groups. The Exp 2 explored the effec

SUBMITTER: Pan F 

PROVIDER: S-EPMC6895446 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature