APOL1 Nephropathy Risk Alleles and Risk of Sepsis in Blacks.

ABSTRACT:

Background and objectives

apo L1 (APOL1) nephropathy risk alleles are associated with CKD in blacks. Although APOL1 has innate immune functions, little is known about the association of APOL1 genotypes with risk of infectious outcomes, such as sepsis. The objective of this study was to examine the associations of APOL1 nephropathy risk alleles with risk of sepsis in black adults.

Design, setting, participants, & measurements

We assessed the association of APOL1 risk alleles with incident sepsis in 10,366 black participants of the Reasons for Geographic and Racial Differences in Stroke study enrolled between 2003 and 2007 with follow-up through December 31, 2012. In Cox models adjusted for demographics, comorbid conditions, and principal components

SUBMITTER: Chaudhary NS 

PROVIDER: S-EPMC6895473 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature