Quantifying Donor Effects on Transplant Outcomes Using Kidney Pairs from Deceased Donors.

ABSTRACT:

Background and objectives

In kidney transplantation, the relative contribution of donor versus other factors on clinical outcomes is unknown. We sought to quantify overall donor effects on transplant outcomes for kidney donations from deceased donors.

Design, setting, participants, & measurements

For paired donations from deceased donors resulting in transplants to different recipients, the magnitude of donor effects can be quantified by examining the excess of concordant outcomes within kidney pairs beyond chance concordance. Using data from the Organ Procurement and Transplantation Network between the years 2013 and 2017, we examined concordance measures for delayed graft function, death-censored 1-year graft failure, and death-censored 3-year graft failure. The concordanc

SUBMITTER: Kerr KF 

PROVIDER: S-EPMC6895487 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature