Testing Models of mRNA Localization Reveals Robustness Regulated by Reducing Transport between Cells.

ABSTRACT: Robust control of gene expression in both space and time is of central importance in the regulation of cellular processes and for multicellular development. However, the mechanisms by which robustness is achieved are generally not identified or well understood. For example, messenger RNA (mRNA) localization by molecular motor-driven transport is crucial for cell polarization in numerous contexts, but the regulatory mechanisms that enable this process to take place in the face of noise or significant perturbations are not fully understood. Here, we use a combined experimental-theoretical approach to characterize the robustness of gurken/transforming growth factor-α mRNA localization in Drosophila egg chambers, where the oocyte and 15 surrounding nurse cells are connected in a stereotypic ne

SUBMITTER: Harrison JU 

PROVIDER: S-EPMC6895595 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature