Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology.

ABSTRACT: Mice with the C3H background show greater behavioral propensity for schizophrenia, including lower prepulse inhibition (PPI), than C57BL/6 (B6) mice. To characterize as-yet-unknown pathophysiologies of schizophrenia, we undertook proteomics analysis of the brain in these strains, and detected elevated levels of Mpst, a hydrogen sulfide (H₂ S)/polysulfide-producing enzyme, and greater sulfide deposition in C3H than B6 mice. Mpst-deficient mice exhibited improved PPI with reduced storage sulfide levels, while Mpst-transgenic (Tg) mice showed deteriorated PPI, suggesting that "sulfide stress" may be linked to PPI impairment. Analysis of human samples demonstrated that the H₂ S/polysulfides production system is upregulated in schizophrenia. Mechanistically, the Mpst-Tg br

SUBMITTER: Ide M 

PROVIDER: S-EPMC6895609 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature