Light conditions affect rhythmic expression of aquaporin 5 and anoctamin 1 in rat submandibular glands.

ABSTRACT: Circadian rhythms regulate various physiological functions and are, therefore, essential for health. Light helps regulate the master and peripheral clocks. The secretion rates of saliva and electrolytes follow a circadian rhythm as well. However, the relationship between the molecular mechanism of saliva water secretion and the peripheral circadian rhythm in salivary glands is not yet clear. The transmembrane proteins aquaporin5 (Aqp5) and anoctamin1 (Ano1) are essential for water transport in the submandibular glands (SGs). The purpose of this study was to reveal the effect of light conditioning on the peripheral clock in SGs. We examined temporal expression patterns among clock genes, Aqp5 and Ano1, in rat SGs under light/dark (LD) and dark/dark (DD) condition

SUBMITTER: Satou R 

PROVIDER: S-EPMC6895735 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature