Continuous Dynamic Modeling of Regulated Cell Adhesion: Sorting, Intercalation, and Involution.

ABSTRACT: Cell-cell adhesion is essential for tissue growth and multicellular pattern formation and crucial for the cellular dynamics during embryogenesis and cancer progression. Understanding the dynamical gene regulation of cell adhesion molecules (CAMs) responsible for the emerging spatial tissue behaviors is a current challenge because of the complexity of these nonlinear interactions and feedback loops at different levels of abstraction-from genetic regulation to whole-organism shape formation. To extend our understanding of cell and tissue behaviors due to the regulation of adhesion molecules, here we present a novel, to our knowledge, model for the spatial dynamics of cellular patterning, growth, and shape formation due to the differential expression of CAMs and their regulation. Capturing th

SUBMITTER: Ko JM 

PROVIDER: S-EPMC6895740 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature