High Clinical Value of Liquid Biopsy to Detect Circulating Tumor Cells and Tumor Exosomes in Pancreatic Ductal Adenocarcinoma Patients Eligible for Up-Front Surgery.

ABSTRACT:

Purpose

Expediting the diagnosis of pancreatic ductal adenocarcinoma (PDAC) would benefit care management, especially for the start of treatments requiring histological evidence. This study evaluated the combined diagnostic performance of circulating biomarkers obtained by peripheral and portal blood liquid biopsy in patients with resectable PDAC.

Experimental design

Liquid biopsies were performed in a prospective translational clinical trial (PANC-CTC #NCT03032913) including 22 patients with resectable PDAC and 28 noncancer controls from February to November 2017. Circulating tumor cells (CTCs) were detected using the CellSearch^® method or after RosetteSep^® enrichment combined with CRISPR/Cas9-improved KRAS mutant alleles quantification by dropl

SUBMITTER: Buscail E 

PROVIDER: S-EPMC6895804 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature