Genome-Wide Association Study of Body Mass Index and Body Fat in Mexican-Mestizo Children.

ABSTRACT:

Background

Childhood obesity is a major health problem in Mexico. Obesity prevalence estimated by body mass index (BMI) is almost half than that estimated by percent body fat (%BF) in the Childhood Obesity pediatric cohort (COIPIS).

Objective

We performed a genome-wide association study (GWAS) of BMI and %BF in 828 children from the COIPIS to identify markers of predisposition to high values for both phenotypes used for obesity classification.

Methods

For the GWAS we used the LAT Axiom 1, Affymetrix and 2.5 million single loci from the 1000 Genomes Phase 3 imputation panel. We used a linear model, adjusted by age, sex, and Amerindian ancestry assuming an additive inheritance model.

Results

Genome-wide significance (p ≤ 5.0 × 10^-8) and 80% of statisti

SUBMITTER: Costa-Urrutia P 

PROVIDER: S-EPMC6895864 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature