Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia?

ABSTRACT: (1) Background: Early identification of mild cognitive impairment (MCI) in people reporting subjective cognitive complaints (SCC) and the study of progression of cognitive decline are important issues in dementia research. This paper examines whether empirically derived procedures predict progression from MCI to dementia. (2) Methods: At baseline, 192 participants with SCC were diagnosed according to clinical criteria as cognitively unimpaired (70), single-domain amnestic MCI (65), multiple-domain amnestic MCI (33) and multiple-domain non-amnestic MCI (24). A two-stage hierarchical cluster analysis was performed for empirical classification. Categorical regression analysis was then used to assess the predictive value of the clusters obtained. Participants were re-assessed after 36 months.

SUBMITTER: Picon E 

PROVIDER: S-EPMC6895967 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature