Bulk and Single-Cell Next-Generation Sequencing: Individualizing Treatment for Colorectal Cancer.

ABSTRACT: The increasing incidence combined with constant rates of early diagnosis and mortality of colorectal cancer (CRC) over the past decade worldwide, as well as minor overall survival improvements in the industrialized world, suggest the need to shift from conventional research and clinical practice to the innovative development of screening, predictive and therapeutic tools. Explosive integration of next-generation sequencing (NGS) systems into basic, translational and, more recently, basket trials is transforming biomedical and cancer research, aiming for substantial clinical implementation as well. Shifting from inter-patient tumor variability to the precise characterization of intra-tumor genetic, genomic and transcriptional heterogeneity (ITH) via multi-regional bulk tissue NGS and emergi

SUBMITTER: Kyrochristos ID 

PROVIDER: S-EPMC6895993 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature