Vestibular Compensation after Vestibular Dysfunction Induced by Arsanilic Acid in Mice.

ABSTRACT: When vestibular function is lost, vestibular compensation works for the reacquisition of body balance. For the study of vestibular dysfunction and vestibular compensation, surgical or chemical labyrinthectomy has been performed in various animal species. In the present study, we performed chemical labyrinthectomy using arsanilic acid in mice and investigated the time course of vestibular compensation through behavioral observations and histological studies. The surgical procedures required only paracentesis and storage of 50 µL of p-arsanilic acid sodium salt solution in the tympanic cavity for 5 min. From behavioral observations, vestibular functions were worst at 2 days and recovered by 7 days after surgery. Spontaneous nystagmus appeared at 1 day after surgery with arsanilic acid and di

SUBMITTER: Ito T 

PROVIDER: S-EPMC6896078 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature