Cell-Specific DNA Methylation Signatures in Asthma.

ABSTRACT: Asthma is a complex trait, often associated with atopy. The genetic contribution has been evidenced by familial occurrence. Genome-wide association studies allowed for associating numerous genes with asthma, as well as identifying new loci that have a minor contribution to its phenotype. Considering the role of environmental exposure on asthma development, an increasing amount of literature has been published on epigenetic modifications associated with this pathology and especially on DNA methylation, in an attempt to better understand its missing heritability. These studies have been conducted in different tissues, but mainly in blood or its peripheral mononuclear cells. However, there is growing evidence that epigenetic changes that occur in one cell type cannot be directly translated in

SUBMITTER: Hudon Thibeault AA 

PROVIDER: S-EPMC6896152 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature