Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice.

ABSTRACT: The prevalence and progression of many illnesses, such as neurodegenerative and cardiovascular diseases, obesity, and cancer, vary between women and men, often in an age-dependent manner. A joint hallmark of these diseases is some type of mitochondrial dysfunction. While several mitochondrial proteins are known to be regulated by sex hormones, the levels of those proteins have not been systematically analyzed with regard to sex and age, and studies that consider sex and/or age differences in the protein expression are very rare. In this study, we compared the expression patterns of physiologically important mitochondrial proteins in female and male C57BL/6N mice of age cohorts frequently used in experiments. We found that sex-related differences in the expression of uncoupling proteins 1 a

SUBMITTER: Moschinger M 

PROVIDER: S-EPMC6896328 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature