Anti-HIV-1 protease activity of the crude extracts and isolated compounds from Auricularia polytricha.

ABSTRACT:

Background

Acquired immunodeficiency syndrome (AIDS) is caused by the Human immunodeficiency virus type-1 (HIV-1). HIV-1 protease (HIV-1 PR) is an essential enzyme for the HIV replication, and therefore, it is an important target for antiretroviral drugs development, particularly from natural products. Auricularia polytricha (AP) is an edible mushroom with several important therapeutic properties. These properties will be investigated as HIV-1 PR inhibitors.

Methods

The sequential hexane (APH), ethanol (APE) and water (APW) extracts from AP were screened for inhibitory activity against HIV-1 PR. The extract that consistently showed the strong HIV-1 PR inhibition was further investigated for its phytochemical constituents. The compounds were purified by column chromatography.

SUBMITTER: Sillapachaiyaporn C 

PROVIDER: S-EPMC6896332 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature