Progression to dementia in memory clinic patients with mild cognitive impairment and normal β-amyloid.

ABSTRACT: BACKGROUND:Determination of β-amyloid (Aβ) positivity and likelihood of underlying Alzheimer's disease (AD) relies on dichotomous biomarker cut-off values. Individuals with mild cognitive impairment (MCI) and Aβ within the normal range may still have a substantial risk of developing dementia, primarily of Alzheimer type. Their prognosis, as well as predictors of clinical progression, are not fully understood. The aim of this study was to explore the associations of cerebrospinal fluid (CSF) biomarkers (Aβ42, total tau, phosphorylated tau) and other characteristics, including modifiable vascular factors, with the risk of progression to dementia among patients with MCI and normal CSF Aβ42. METHODS:Three hundred eighteen memory clinic patients with CSF and clinical data, and at least 1-year f

SUBMITTER: Rosenberg A 

PROVIDER: S-EPMC6896336 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature