The effect of antenatal depression and antidepressant treatment on placental tissue: a protein-validated gene expression study.

ABSTRACT:

Background

Antenatal depression affects 10-20% of pregnant women. Around 2-4% of European pregnant women use antidepressant treatment, most commonly selective serotonin reuptake inhibitors (SSRIs). Poor pregnancy outcomes, such as preterm birth and low birth weight, have been described in women with antenatal depression and in pregnant women on SSRI treatment. However, the effects of antenatal depression and antidepressant treatment on the placenta are largely unknown. The aim of this work was to compare placental gene and protein expression in healthy women, women with untreated antenatal depression and women on antidepressant treatment during pregnancy.

Methods

Placental samples from 47 controls, 25 depressed and 45 SSRI-treated women were analysed by means of qPCR using c

SUBMITTER: Edvinsson A 

PROVIDER: S-EPMC6896358 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature