Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma.

ABSTRACT: The gasdermin (GSDM) superfamily has been demonstrated to consist of several important molecules that modulate multifunctional signal processes, such as cell pyroptosis. In this research, the roles of the GSDM superfamily on the occurrence and prognosis of lung adenocarcinoma (LUAD) were evaluated using integrative bioinformatic analyses and in vitro methods. Here, data from several bioinformatic platforms revealed that GSDMC is significantly upregulated in LUAD tissues and cell lines. Real‑time fluorescence quantitative PCR (qPCR) demonstrated that GSDMC was obviously upregulated in radio‑resistant LUAD cells, compared with their parental cells. Moreover, upregulated GSDMC expression was confirmed to be an independent indicator of poor first progression (FP) and overall survival (OS) in L

SUBMITTER: Wei J 

PROVIDER: S-EPMC6896373 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature