A meta-analysis of the effects of therapeutic hypothermia in adult patients with traumatic brain injury.

ABSTRACT: PURPOSE:Therapeutic hypothermia management remains controversial in patients with traumatic brain injury. We conducted a meta-analysis to evaluate the risks and benefits of therapeutic hypothermia management in patients with traumatic brain injury. METHODS:We searched the Web of Science, PubMed, Embase, Cochrane (Central) and Clinical Trials databases from inception to January 17, 2019. Eligible studies were randomised controlled trials that investigated therapeutic hypothermia management versus normothermia management in patients with traumatic brain injury. We collected the individual data of the patients from each included study. Meta-analyses were performed for 6-month mortality, unfavourable functional outcome and pneumonia morbidity. The risk of bias was evaluated using the Cochrane

SUBMITTER: Chen H 

PROVIDER: S-EPMC6896404 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature