A preliminary investigation of rare variants associated with genetic risk for PTSD in a natural disaster-exposed adolescent sample.

ABSTRACT: Background: Posttraumatic stress disorder (PTSD) involves a complex interaction of biological, psychological, and social factors. Numerous studies have demonstrated genetic variation associated with the development of PTSD, primarily in adults. However, the contribution of low frequency and rare genetic variants to PTSD is unknown to date. Moreover, there is limited work on genetic risk for PTSD in child and adolescent populations. Objective: This preliminary study aimed to identify the low frequency and rare genetic variation that contributes to PTSD using an exome array. Method: This post-disaster, adolescent sample (n = 707, 51% females, M _age = 14.54) was assessed for PTSD diagnosis and symptom count following tornado exposure. Results: Gen

SUBMITTER: Sheerin CM 

PROVIDER: S-EPMC6896412 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature