Resurgence of malaria infection after mass treatment: a simulation study.

ABSTRACT: BACKGROUND:Field studies are evaluating if mass drug administration (MDA) might shorten the time to elimination of Plasmodium falciparum malaria, when vector control measures and reactive surveillance strategies are scaled-up. A concern with this strategy is that there may be resurgence of transmission following MDA. METHODS:A conceptual model was developed to classify possible outcomes of an initial period of MDA, followed by continuously implementing other interventions. The classification considered whether elimination or a new endemic stable state is achieved, and whether changes are rapid, transient, or gradual. These categories were informed by stability analyses of simple models of vector control, case management, and test-and-treat interventions. Individual-based stochastic models

SUBMITTER: Smith TA 

PROVIDER: S-EPMC6896478 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature