Ages of hepatocellular carcinoma occurrence and life expectancy are associated with a UGT2B28 genomic variation.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is an aggressive solid tumor. HCC occurred at younger and elder ages were considered driven by different oncogenic mechanisms, and they demonstrated distinct clinical courses.

Methods

A total of 382 HCC patients treated by surgical resections was analyzed.

Results

A univariate-multivariate analysis showed that viral etiology (chronic hepatitis B, C) and the UDP glucuronosyltransferase family 2 member B28 (UGT2B28) genomic variant rs2132039 were independently associated with the age at presentation of HCC (all adjusted P < 0.05). An extensive evaluations of clinicalpathological factors showed that the age (Odds ratio [OR], 1.016; 95% confidence interval [CI], 1.001-1.032; adjusted P = 0.037) and ascites (OR, 3.505; CI, 1.358-9.

SUBMITTER: Le PH 

PROVIDER: S-EPMC6896495 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature