BEST: a web server for brain expression Spatio-temporal pattern analysis.

ABSTRACT: BACKGROUND:Dysregulated gene expression patterns have been reported in several mental disorders. Limited by the difficulty of obtaining samples, psychiatric molecular mechanism research still relies heavily on clues from genetics studies. By using reference data from brain expression studies, multiple types of comprehensive gene expression pattern analysis have been performed on psychiatric genetic results. These systems-level spatial-temporal expression pattern analyses provided evidence on specific brain regions, developmental stages and molecular pathways that are possibly involved in psychiatric pathophysiology. At present, there is no online tool for such systematic analysis, which hinders the applications of analysis by non-informatics researchers such as experimental biologists and

SUBMITTER: Guo L 

PROVIDER: S-EPMC6896511 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature