Phase-Dependent Response to Afferent Stimulation During Fictive Locomotion: A Computational Modeling Study.

ABSTRACT: Central pattern generators (CPGs) in the spinal cord generate rhythmic neural activity and control locomotion in vertebrates. These CPGs operate under the control of sensory feedback that affects the generated locomotor pattern and adapt it to the animal's biomechanics and environment. Studies of the effects of afferent stimulation on fictive locomotion in immobilized cats have shown that brief stimulation of peripheral nerves can reset the ongoing locomotor rhythm. Depending on the phase of stimulation and the stimulated nerve, the applied stimulation can either shorten or prolong the current locomotor phase and the locomotor cycle. Here, we used a mathematical model of a half-center CPG to investigate the phase-dependent effects of brief stimulation applied to CPG on the CPG-generated lo

SUBMITTER: Fujiki S 

PROVIDER: S-EPMC6896512 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature