The efficacy and safety of intravenous tranexamic acid in hip fracture surgery: A systematic review and meta-analysis.

ABSTRACT:

Objective

The present meta-analysis was conducted to compare the efficacy and safety of intravenous application of tranexamic acid (TXA) with placebo in patients with hip fracture undergoing hip surgeries.

Methods

PubMed, EMBASE and Cochrane Library were searched from inception until March 2018. A combined searching strategy of subject words and random words was adopted. Only randomized clinical trials were included. The comparisons regarding transfusion rate, total blood loss, intraoperative blood loss, postoperative blood loss, postoperative haemoglobin and postoperative thromboembolic complications were conducted. The meta-analysis was performed using Review Manager 5.3, and the bias evaluation was based on the Cochrane Handbook 5.1.0.

Results

Ten randomized contro

SUBMITTER: Qi YM 

PROVIDER: S-EPMC6896672 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature