Association of Functional Polymorphisms of KIR3DL1/DS1 With Behcet's Disease.

ABSTRACT: Behçet's disease (BD) is an immune-mediated vasculitis related to imbalances between the innate and adaptive immune response. Infectious agents or environmental factors may trigger the disease in genetically predisposed individuals. HLA-B51 is the genetic factor stronger associated with the disease, although the bases of this association remain elusive. NK cells have also been implicated in the etiopathogenesis of BD. A family of NK receptors, Killer-cell Immunoglobulin-like Receptor (KIR), with a very complex organization, is very important in the education and control of the NK cells by the union to their ligands, most of them, HLA class I molecules. This study aimed to investigate the contribution of certain KIR functional polymorphisms to the susceptibility to BD. A total of 466 BD pat

SUBMITTER: Castano-Nunez A 

PROVIDER: S-EPMC6896819 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature