Histone Tail Dynamics in Partially Disassembled Nucleosomes During Chromatin Remodeling.

ABSTRACT: Nucleosomes are structural units of the chromosome consisting of DNA wrapped around histone proteins, and play important roles in compaction and regulation of the chromatin structure. While the structure and dynamics of canonical nucleosomes have been studied extensively, those of nucleosomes in intermediate states, that occur when their structure or positioning is modulated, have been less understood. In particular, the dynamic features of partially disassembled nucleosomes have not been discussed in previous studies. Using all-atom molecular dynamics simulations, in this study, we investigated the dynamics and stability of nucleosome structures lacking a histone-dimer. DNA in nucleosomes lacking a histone H2A/H2B dimer was drastically deformed due to loss of local interactions between DN

SUBMITTER: Kameda T 

PROVIDER: S-EPMC6896900 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature